RNA Details
Disease Name
skin fibrosis
Tissue
skin
RNA Symbol
mir-149
RNA ID
RNA Type
miRNA
Alteration Pattern
dysregulation
Species
mus musculus
Detection Methods
qRT-PCR; enzyme-linked immunosorbent assay; etc.
Target
NA
Pathway
NA
PubMed ID
Title
MicroRNA-149 contributes to scarless wound healing by attenuating inflammatory response
Year
2017
Function
"Mir 149 was revealed to indirectly accelerate transforming growth factor beta3 and collagen type iii expression in fibroblasts, which are essential cells in extracellular matrix remodeling. In a rat skin wound model, mir 149 improved the quality of the arrangement of collagen bundles and reduced inflammatory cell infiltration during skin wound healing. These results indicate that mir 149 may be a potential regulator in improving the quality of skin wound healing."